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A Novel Tandem Duplication Assay to Detect Minimal Residual Disease in FLT3/ITD AML.

Ming-Tseh LinLi-Hui TsengJonathan C DudleyStacey RielHarrison TsaiGang ZhengKeith W PratzMark J LevisChristopher D Gocke
Published in: Molecular diagnosis & therapy (2016)
Detection of MRD by TD-PCR may guide patient selection for early clinical intervention. In contrast to clone-specific approaches, the TD-PCR assay can be more easily validated for MRD detection in clinical laboratories because it uses standardized primers and a universal positive control. In addition, our findings on multi-clonality and low-level ITDs suggest that further studies are warranted to elucidate their clinical/biological significance.
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