Impact of high platelet turnover on the platelet transcriptome: Results from platelet RNA-sequencing in patients with sepsis.

Thomas G NührenbergJasmin StöckleFederico MariniMark ZurekBjörn A GrüningVladimir BenesLutz HeinFranz-Josef NeumannChristian StratzMarco CederqvistWillibald Hochholzer

Published in: PloS one (2022)

Patients with sepsis appear to have a less degraded platelet transcriptome as indicated by increased levels of immature platelets and decreased levels of putative circular RNA transcripts. The present data suggests that increased protein translation is a characteristic mechanism of systemic inflammation.

Keyphrases

single cell
acute kidney injury
rna seq
intensive care unit
gene expression
genome wide
septic shock
machine learning
binding protein
postmenopausal women
artificial intelligence