KDM6A promotes chondrogenic differentiation of periodontal ligament stem cells by demethylation of SOX9.
Pingting WangYanjing LiTingting MengJunjiang ZhangYuanyuan WeiZhaosong MengYunfeng LinDayong LiuLei SuiPublished in: Cell proliferation (2017)
KDM6A is required in chondrogenic differentiation of PDLSCs by demethylation of H3K27me3, and EZH2 inhibitor could rescue chondrogenesis of PDLSCs after knockdown of KDM6A. It could be inferred that upregulation of KDM6A or application of EZH2 inhibitor might improve mesenchymal stem cell mediated cartilage regeneration in inflammatory tissue destruction such as osteoarthritis.