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"Seeing Is Believing": Additive Utility of 68 Ga-PSMA-11 PET/CT in Prostate Cancer Diagnosis.

Joel ChinYu Guang TanAlvin LeeTze Kiat NgRuoyu ShiCharlene Yu Lin TangSue Ping ThangJeffrey Kit Loong TuanChristopher Wai Sam ChengKae Jack TayHenry Sun Sien HoHung-Jen WangPeter Ka-Fung ChiuJeremy Yuen Chun TeohWinnie Wing-Chuen LamYan Mee LawJohn Shyi Peng YuenKenneth Chen
Published in: Cancers (2024)
Widespread adoption of mpMRI has led to a decrease in the number of patients requiring prostate biopsies. 68 Ga-PSMA-11 PET/CT has demonstrated added benefits in identifying csPCa. Integrating the use of these imaging techniques may hold promise for predicting the presence of csPCa without invasive biopsy. A retrospective analysis of 42 consecutive patients who underwent mpMRI, 68 Ga-PSMA-11 PET/CT, prostatic biopsy, and radical prostatectomy (RP) was carried out. A lesion-based model ( n = 122) using prostatectomy histopathology as reference standard was used to analyze the accuracy of 68 Ga-PSMA-11 PET/CT, mpMRI alone, and both in combination to identify ISUP-grade group ≥ 2 lesions. 68 Ga-PSMA-11 PET/CT demonstrated greater specificity and positive predictive value (PPV), with values of 73.3% (vs. 40.0%) and 90.1% (vs. 82.2%), while the mpMRI Prostate Imaging Reporting and Data System (PI-RADS) 4-5 had better sensitivity and negative predictive value (NPV): 90.2% (vs. 78.5%) and 57.1% (vs. 52.4%), respectively. When used in combination, the sensitivity, specificity, PPV, and NPV were 74.2%, 83.3%, 93.2%, and 51.0%, respectively. Subgroup analysis of PI-RADS 3, 4, and 5 lesions was carried out. For PI-RADS 3 lesions, 68 Ga-PSMA-11 PET/CT demonstrated a NPV of 77.8%. For PI-RADS 4-5 lesions, 68 Ga-PSMA-11 PET/CT achieved PPV values of 82.1% and 100%, respectively, with an NPV of 100% in PI-RADS 5 lesions. A combination of 68 Ga-PSMA-11 PET/CT and mpMRI improved the radiological diagnosis of csPCa. This suggests that avoidance of prostate biopsy prior to RP may represent a valid option in a selected subgroup of high-risk patients with a high suspicion of csPCa on mpMRI and 68 Ga-PSMA-11 PET/CT.
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