Hyperglycemia Affects the Expression of Inflammatory Genes in Peripheral Blood Mononuclear Cells of Patients with Type 2 Diabetes.

Published in: Immunological investigations (2018)

The observed changes in both IL-1β and IL-6 mRNA levels in PBMCs may contribute to the development of inflammatory processes involved in the pathogenesis of T2D. Downregulation of IL1R1 in individuals with mild hyperglycemia may indicate an attempt to reduce the pro-inflammatory effects of IL-1β via auto-stimulation.

Keyphrases

oxidative stress
poor prognosis
cell proliferation
signaling pathway
binding protein
genome wide
gene expression
diabetic rats
long non coding rna