NTRK expression is common in xanthogranuloma and is associated with the solitary variant.

B UmphressM KuharR KowalAhmed K AlomariL A BaldridgeA J RossSimon J Warren

Published in: Journal of cutaneous pathology (2023)

NTRK expression is common in JXG or AXG and associated with localized rather than disseminated disease. We speculate that the potential importance of this in JXG and AXG has not been previously appreciated due to the tendency to focus sequencing studies on disseminated disease. We confirm the presence of an NTRK1 fusion in two positive cases by NGS, however, additional genetic studies are necessary to further explore this.

Keyphrases

poor prognosis
case control
binding protein
long non coding rna
single cell
genome wide
gene expression
copy number
dna methylation