Is there an acceptable surrogate for caries clinical trials? Evidence from a systematic review of primary studies.
Thais GimenezLuana Rodrigues EstevamYohana de Oliveira PonteAdriana DalboniAna Flávia Bissoto CalvoTamara Kerber TedescoLaura Regina Antunes PontesBruna Lorena Pereira MoroDaniela Prócida RaggioMariana Minatel BragaFausto Medeiros MendesPublished in: Community dentistry and oral epidemiology (2023)
Loss of retention of sealants and the presence of white spot lesions do not fulfil all of the Prentice criteria. Therefore, they cannot be considered valid surrogates for caries prevention.