Targeting nicotinamide N-methyltransferase decreased aggressiveness of osteosarcoma cells.
E N SerritelliD SartiniR CampagnaValentina PozziN I MartinM J van HarenE SalvoliniM CecatiC RubiniM EmanuelliPublished in: European journal of clinical investigation (2024)
Results showed that OS samples display a significantly higher NNMT expression compared with healthy tissue. Preliminary results suggest that NNMT silencing in OS cell lines is associated to a decrease of cell proliferation and migration, as well as to enhanced sensitivity to chemotherapy. Data obtained showed that NNMT may represent an interesting marker for OS detection and a promising target for effective anti-cancer therapy.
Keyphrases
- cancer therapy
- induced apoptosis
- drug delivery
- poor prognosis
- cell cycle arrest
- electronic health record
- cell therapy
- big data
- locally advanced
- endoplasmic reticulum stress
- oxidative stress
- stem cells
- machine learning
- squamous cell carcinoma
- loop mediated isothermal amplification
- signaling pathway
- long non coding rna
- binding protein
- data analysis
- bone marrow
- deep learning
- quantum dots