The Association of Gut Microbiota With Osteoporosis Is Mediated by Amino Acid Metabolism: Multiomics in a Large Cohort.
Chu-Wen LingZelei MiaoMian-Li XiaoHongwei ZhouZengliang JiangYuanqing FuFeng XiongLuo-Shi-Yuan ZuoYu-Ping LiuYan-Yan WuLi-Peng JingHong-Li DongGeng-Dong ChenDing DingCheng WangFang-Fang ZengHui-Lian ZhuYan HeJu-Sheng ZhengYu-Ming ChenPublished in: The Journal of clinical endocrinology and metabolism (2021)
This large population-based study provided robust evidence connecting gut dysbiosis, fecal metabolomics, and serum metabolomics with osteoporosis. Our results suggest that gut dysbiosis and amino acid metabolism could be targets for intervention in osteoporosis.