Immunization with a heat-killed bacterium, Mycobacterium vaccae NCTC 11659, prevents the development of cortical hyperarousal and a PTSD-like sleep phenotype after sleep disruption and acute stress in mice.
Samuel J BowersSophie LambertShannon HeChristopher A LowryMonika FleshnerKenneth P WrightFred W TurekMartha Hotz VitaternaPublished in: Sleep (2021)
Immunization with MV ameliorates a stress-induced sleep and behavioral phenotype that shares features with human posttraumatic stress disorder.
Keyphrases
- stress induced
- posttraumatic stress disorder
- sleep quality
- physical activity
- endothelial cells
- liver failure
- mouse model
- mycobacterium tuberculosis
- heat stress
- respiratory failure
- adipose tissue
- type diabetes
- social support
- induced pluripotent stem cells
- intensive care unit
- high fat diet induced
- hepatitis b virus
- mechanical ventilation
- wild type