Extended Versus Standard Proning Duration for COVID-19 Associated Acute Respiratory Distress Syndrome: A Target Trial Emulation Study.
Chad H HochbergElizabeth ColantuoniSarina K SahetyaMichelle N EakinEddy FanKevin J PsoterTheodore J IwashynaDale M NeedhamDavid N HagerPublished in: Annals of the American Thoracic Society (2024)
Using target trial emulation, we found no significant effect of extended vs. standard proning duration on mortality, ventilator liberation, or ICU discharge. However, given the imprecision of estimates, further study is justified. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keyphrases
- acute respiratory distress syndrome
- mechanical ventilation
- extracorporeal membrane oxygenation
- phase iii
- study protocol
- phase ii
- clinical trial
- coronavirus disease
- sars cov
- intensive care unit
- cardiovascular events
- minimally invasive
- randomized controlled trial
- risk factors
- cardiovascular disease
- type diabetes
- placebo controlled