Reactive Oxygen Species Induced Upregulation of TRPV1 in Dorsal Root Ganglia Results in Low Back Pain in Rats.

Xinyong ChenZhe ChenGongchang MaJianjun ShaShan ZhaoZuoqing LiuNong ChenHuilin Yang

Published in: Journal of inflammation research (2024)

Increased ROS in DRGs play a primary pathological role in puncture-induced discogenic LBP, and excessive ROS-induced upregulation of TRPV1 in DRGs may be the underlying pathophysiological mechanism to cause nerve sensitization and discogenic LBP. Therapeutic targeting of ROS or TRPV1 in DRGs may provide a promising method for the treatment of discogenic LBP.

Keyphrases

reactive oxygen species
high glucose
diabetic rats
neuropathic pain
cell death
dna damage
drug induced
poor prognosis
signaling pathway
endothelial cells
physical activity
body mass index
spinal cord injury
weight gain
replacement therapy