Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins.
Dyonne Y VosMelinde WijersMarieke SmitNicolette HuijkmanNiels J KloosterhuisJustina Clarinda WoltersJoël J TissinkAmanda C M PronkSander KooijmanPatrick C N RensenJan Albert KuivenhovenBart van de SluisPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Our study suggests that VPS35L is shared between retriever and CCC to facilitate LDLR and LRP1 transport from endosomes to the cell surface. Conversely, retriever subunit VPS26C selectively transports LRP1, but not LDLR, and thereby may control hepatic uptake of postprandial TG-rich lipoprotein remnants.