P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage.
Christopher T LairdWessam HassaneinNatalie A O'NeillBeth M FrenchXiangfei ChengWilliam E FoglerJohn L MagnaniDawn ParsellArielle CimenoCarol J PhelpsDavid AyaresLars BurdorfAgnes M AzimzadehRichard N PiersonPublished in: Xenotransplantation (2018)
Selectin blockade may be useful as part of an integrated strategy to prevent neutrophil-mediated organ xenograft injury, especially during the early time points following reperfusion.
Keyphrases
- endothelial cells
- acute myocardial infarction
- oxidative stress
- cerebral ischemia
- induced pluripotent stem cells
- pluripotent stem cells
- mouse model
- escherichia coli
- coronary artery disease
- binding protein
- acute coronary syndrome
- staphylococcus aureus
- blood brain barrier
- cell migration
- percutaneous coronary intervention