In vivo overexpression of synaptogyrin-3 promotes striatal synaptic dopamine uptake in LRRK2 R1441G mutant mouse model of Parkinson's disease.
Philip Wing-Lok HoLingfei LiHui-Fang LiuZoe Yuen-Kiu ChoiEunice Eun Seo ChangShirley Yin-Yu PangYasine MalkiChi-Ting LeungMichelle Hiu-Wai KungDavid Boyer RamsdenShu-Leong HoPublished in: Brain and behavior (2023)
Brain SYNGR3 expression may be an important determinant to striatal DA homeostasis and synaptic function. Our preliminary behavioral test showed improved innate behavior after SYNGR3 overexpression in LRRK2 mutant mice, advocating further studies to determine the influence of SYNGR3 in the pathophysiology of DA neurons in PD.
Keyphrases
- wild type
- functional connectivity
- resting state
- prefrontal cortex
- mouse model
- parkinson disease
- cell proliferation
- immune response
- poor prognosis
- transcription factor
- spinal cord
- white matter
- uric acid
- high fat diet induced
- deep brain stimulation
- case control
- binding protein
- adipose tissue
- type diabetes
- cerebral ischemia
- multiple sclerosis
- insulin resistance