Tumor Lysis Syndrome and AKI: Beyond Crystal Mechanisms.

Marine ArnaudMaud LoiselleCamille VaganayStéphanie PonsEmmanuel LetavernierJordane DemonchySofiane FodilManal NouacerSandrine PlacierPerrine FrèreEden ArriiJulien LionNuala MooneyRaphael ItzyksonChakib DjediatAlexandre PuissantLara Zafrani

Published in: Journal of the American Society of Nephrology : JASN (2022)

This study sheds new light on the pathophysiology of TLS-induced AKI and suggests that extracellular histones may constitute a novel target for therapeutic intervention in TLS when endothelial dysfunction occurs.

Keyphrases

acute kidney injury
randomized controlled trial
high glucose
diabetic rats
case report
oxidative stress
endothelial cells
solid state