Shugoshin 2-a new guardian for heat shock transcription.

Amoldeep S KainthRajyalakshmi MeduriVickky PanditLinda S RubioDavid S Gross

Published in: The EMBO journal (2019)

Takii et al (2019) demonstrate in a recent issue of The EMBO Journal that the pericentromeric protein, SGO2, serves as a novel transcriptional coactivator of HSF1, contributing to PIC assembly and expression of Heat Shock Protein (HSP) genes. This finding highlights repurposing of a protein with a nuclear function to drive transcription of proteotoxic stress machinery genes.

Keyphrases

genome wide analysis
heat shock
heat shock protein
heat stress
binding protein
transcription factor
poor prognosis
protein protein
amino acid
oxidative stress
genome wide
long non coding rna
stress induced
bioinformatics analysis
genome wide identification