Biosurfactant complexed with arginine has antibiofilm activity against methicillin-resistant Staphylococcus aureus .
Fatima Daiana Dias BarrosoLisandra Juvêncio da SilvaHelaine Almeida QueirozLívia Gurgel do Amaral Valente SáAnderson Ramos da SilvaCecília Rocha da SilvaJoão Batista de Andrade NetoBruno Coêlho CavalcantiManoel Odorico de MoraesAurora PinazoLourdes PérezHélio Vitoriano Nobre JúniorPublished in: Future microbiology (2024)
Aim: The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant Staphylococcus aureus (MRSA). Methodology: Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol: M07-A10, checkerboard test, biofilm in plates and catheters and flow cytometry were used. Result: RLMIX_Arg has bactericidal and synergistic activity with oxacillin. RLMIX_Arg inhibits the formation of MRSA biofilms on plates at sub-inhibitory concentrations and has antibiofilm action against MRSA in peripheral venous catheters. Catheters impregnated with RLMIX_Arg reduce the formation of MRSA biofilms. Conclusion: RLMIX_Arg exhibits potential for application in preventing infections related to methicillin-resistant S. aureus biofilms.
Keyphrases
- methicillin resistant staphylococcus aureus
- staphylococcus aureus
- candida albicans
- flow cytometry
- biofilm formation
- randomized controlled trial
- nitric oxide
- induced apoptosis
- pseudomonas aeruginosa
- systematic review
- signaling pathway
- cell proliferation
- risk assessment
- cancer therapy
- climate change
- cell cycle arrest
- escherichia coli
- amino acid
- drug induced
- pi k akt
- atomic force microscopy