Atrial fibrosis in non-atrial fibrillation individuals and prediction of atrial fibrillation by use of late gadolinium enhancement magnetic resonance imaging.
Johannes SiebermairPromporn SuksaranjitChristopher J McGannKathryn A PetersonMobin KheirkhahanAlex A BaherKavitha DamalReza WakiliNassir F MarroucheBrent D WilsonPublished in: Journal of cardiovascular electrophysiology (2019)
This study reports unexpectedly high atrial fibrosis in non-AF patients without apparent heart disease, highlighting the concept that structural fibrotic alterations may precede AF onset in a significant proportion of individuals. BMI as a predictor of atrial fibrosis suggests that lifestyle and drug intervention, that is, weight reduction, could positively influence fibrosis development. The derived risk score for AF prevalence provides the basis for prospective studies on AF incidence.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- magnetic resonance imaging
- direct oral anticoagulants
- heart failure
- end stage renal disease
- risk factors
- percutaneous coronary intervention
- body mass index
- physical activity
- randomized controlled trial
- weight loss
- liver fibrosis
- newly diagnosed
- chronic kidney disease
- cardiovascular disease
- metabolic syndrome
- type diabetes
- prognostic factors
- weight gain
- pulmonary hypertension
- diffusion weighted imaging
- emergency department
- coronary artery disease
- systemic sclerosis
- mitral valve