A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease.
Francesca PolverinoJoselyn RojasXiaoyun WangHans PetersenLi ZhangXiaoyan GaiAndrew HighamDuo ZhangKushagra GuptaAmit RoutIlyas YambayevVictor Pinto-PlataLynette M ShollDanen CunoosamyBartolomé R CelliJames GoldringDave SinghYohannes TesfaigziJadwiga WedzichaHenric OlssonCaroline A OwenPublished in: American journal of respiratory and critical care medicine (2019)
Adam8 deficiency increases CS-induced lung inflammation, emphysema, and airway mucus cell metaplasia. Strategies that increase or prolong ADAM8's expression in the lung may have therapeutic efficacy in COPD.