Tumor microenvironment shows an immunological abscopal effect in patients with NSCLC treated with pembrolizumab-radiotherapy combination.
Lieke L van der WoudeMark A J GorrisInge M N WortelJeroen H A CreemersKiek VerrijpKim MonkhorstKatrien GrünbergMichel M van den HeuvelJohannes C TextorCarl G FigdorBerber PietWillemijn S M E TheelenIngrid Jolanda M De VriesPublished in: Journal for immunotherapy of cancer (2022)
This explorative study shows that that lymphocyte infiltration in general, instead of the infiltration of a specific lymphocyte subset, is associated with response to therapy in patients with NSCLC.Furthermore, anti-PD-1+SBRT combination therapy induces an immunological abscopal effect in the TME represented by a superior infiltration of cytotoxic T cells as compared with anti-PD-1 monotherapy.