Dual probe difference specimen imaging for prostate cancer margin assessment.
Marcus J KwonBroderick J HouseConnor W BarthAllison SolankiJocelyn A JonesScott C DavisSummer L GibbsPublished in: Journal of biomedical optics (2023)
Previous work has shown that ratiometic imaging has strong predictive value for breast cancer margin status using topical administration. Translation of the ratiometric DDSI methodology herein from breast to prostate cancers demonstrates it as a robust, ratiometric technique that provides a molecularly specific imaging modality for intraoperative margin detection. Using the validated DDSI protocol on resected prostate cancers permitted rapid and accurate assessment of PSMA status as a surrogate for prostate cancer margin status. Future studies will further evaluate the utility of this technology to quantitatively characterize prostate margin status using PSMA as a biomarker.
Keyphrases
- prostate cancer
- high resolution
- radical prostatectomy
- quantum dots
- living cells
- pet ct
- fluorescent probe
- benign prostatic hyperplasia
- randomized controlled trial
- lymph node
- sensitive detection
- nitric oxide
- loop mediated isothermal amplification
- patients undergoing
- fluorescence imaging
- single molecule
- computed tomography
- photodynamic therapy
- current status
- case control