Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis (MESA).
Katlyn E McGrawKathrin SchillingRonald A GlabonjatMarta Galvez-FernandezArce Domingo-RellosoIrene Martinez-MorataMiranda R JonesWendy S PostJoel Daniel KaufmanMaria Tellez-PlazaLinda ValeriElizabeth R BrownRichard A KronmalGraham R BarrSteven J C SheaAna Navas-AcienTiffany R SanchezPublished in: medRxiv : the preprint server for health sciences (2023)
What is new?Urinary levels of non-essential (cadmium, tungsten, uranium) and essential metals (cobalt, copper, zinc) are associated with coronary artery calcification at baseline and at ten years of follow up in a diverse US sample.What are the clinical implications?Reductions in environmental metal exposure may improve cardiovascular health.Dietary and chelation interventions to reduce metals in the body may improve CVD outcomes.