Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.
Qendresa HotiGokce AkanGulten TuncelEmine Unal EvrenHakan EvrenKaya SuerTamer SanlidagMahmut Çerkez ErgorenPublished in: Molecular biology reports (2023)
TAS1R2, TAS1R3, and TAS2R38 gene expression levels were decreased in the Delta variant compared to the Omicron BA.1 variant in the studied groups. These results provided a significant clue for the temporary taste loss, especially in patients infected with the Delta variant, which is the most disruptive and symptomatic variant causing hospitalizations, and deaths compared to other variants may be because ACE2 is expressed in the taste buds and high replication of SARS-CoV-2 in the infected gustatory cells in the taste bud generates inflammation and then could eventually destroy the cells. This gustatory cell damage may cause malfunction of the gustatory system.
Keyphrases
- sars cov
- induced apoptosis
- gene expression
- oxidative stress
- cell cycle arrest
- end stage renal disease
- copy number
- newly diagnosed
- chronic kidney disease
- ejection fraction
- poor prognosis
- dna methylation
- signaling pathway
- endoplasmic reticulum stress
- prognostic factors
- cell death
- mesenchymal stem cells
- transcription factor
- bone marrow
- long non coding rna
- binding protein
- coronavirus disease
- patient reported
- angiotensin converting enzyme