Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.
Robert KridelFong Chun ChanAnja MottokMerrill BoylePedro FarinhaKing TanBarbara MeissnerAli BashashatiAndrew W McPhersonAndrew RothKarey ShumanskyDamian YapSusana Ben-NeriahJamie RosnerMaia A SmithCydney NielsenEva GinéAdele TeleniusDaisuke EnnishiAndrew J MungallRichard MooreRyan D MorinNathalie A JohnsonLaurie H SehnThomas TousseynAhmet DoganJoseph M ConnorsDavid W ScottChristian SteidlMarco A MarraRandy D GascoyneSohrab P ShahPublished in: PLoS medicine (2016)
Our results illuminate contrasting modes of evolution shaping the clinical histories of transformation and progression. They have implications for interpretation of evolutionary dynamics in the context of treatment-induced selective pressures, and indicate that transformation and progression will require different clinical management strategies.