The presence of neutrophils causes RANKL expression in periodontal tissue, giving rise to osteoclast formation.

Ae Ri KimJi-Hye KimYun Hui ChoiYeong-Eui JeonJeong-Heon ChaEun-Jung Bak Yun-Jung Yoo

Published in: Journal of periodontal research (2020)

Neutrophil deficiency caused a reduction in numbers of both RANKL+ cells and osteoclasts in periodontitis-induced tissues only on day 3. Furthermore, in the LPS-injected air pouch model, neutrophil deficiency reduced the influx of RANKL+ neutrophils. These findings suggest that the presence of neutrophils induces RANKL expression and could induce osteoclast formation in the early stages of periodontitis.

Keyphrases

bone loss
poor prognosis
nuclear factor
induced apoptosis
gene expression
binding protein
cell cycle arrest
diabetic rats
replacement therapy
long non coding rna
high glucose
oxidative stress
signaling pathway
anti inflammatory
drug induced