Increased risk for aseptic meningitis after amoxicillin or amoxicillin-clavulanic acid in males: A signal revealed by subset disproportionality analysis within a global database of suspected adverse drug reactions.

Published in: Pharmacoepidemiology and drug safety (2018)

Subgroup disproportionality analysis has revealed a larger than expected number of reports of aseptic meningitis after amoxicillin and AC in males. Evidence synthesis supports the statistical finding. Further exploration of spontaneous databases with more extensive analyses could usher in a new era of "precision pharmacovigilance."

Keyphrases

adverse drug
electronic health record
emergency department
drug induced
randomized controlled trial
machine learning
cerebrospinal fluid
clinical trial
deep learning
phase iii
double blind