S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos.

Xia WangHongyang HuangKaren Man-Fong SzeJin WangLu TianJingyi LuYu-Man TsuiHoi Tang MaEva LeeAo ChenJoyce LeeYing WangJudy Wai Ping YamTan-To CheungXin-Yuan Guan Irene Oi Lin Ng

Published in: Gut (2023)

Altogether, our results uncovered that S100A10 promotes HCC progression significantly via its transfer in EVs and regulating the protein cargoes of EVs. EV-S100A10 may be a potential therapeutic target and biomarker for HCC progression.

Keyphrases

protein protein
amino acid
binding protein
risk assessment
small molecule
human health