Epigenetic landscape of testis specific histone H2B variant and its influence on sperm function.
Aniket PatankarRahul GajbhiyeSuchitra SurvePriyanka PartePublished in: Clinical epigenetics (2021)
ChIP-seq analysis of TH2B revealed a putative role of TH2B in sperm function and embryo development. Altered expression of TH2B associated genes in infertile individuals with sperm chromatin compaction defects indicates involvement of TH2B in transcriptional regulation of these genes in post meiotic male germ cells. This altered transcriptome may be a consequence or cause of abnormal nuclear remodeling during spermiogenesis.
Keyphrases
- genome wide
- dna methylation
- single cell
- gene expression
- rna seq
- induced apoptosis
- poor prognosis
- high throughput
- cell cycle arrest
- bioinformatics analysis
- dna damage
- polycystic ovary syndrome
- circulating tumor cells
- insulin resistance
- adipose tissue
- cell proliferation
- binding protein
- long non coding rna
- pregnant women
- genome wide analysis
- skeletal muscle
- germ cell