Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours.

Kai FunkeUlf EinsfelderAylin HansenLena ArévaloSimon SchneiderDaniel NettersheimValentin SteinHubert Schorle

Published in: British journal of cancer (2023)

We identified overactivation of neddylation as a factor for cisplatin resistance in TGCTs and highlighted the additive effect of NAE1 inhibition by MLN4924 in combination with cisplatin as a novel treatment option for TGCTs.

Keyphrases

germ cell
genome wide
crispr cas
genome editing
high throughput
gene expression
dna methylation
combination therapy
single cell