Coarctation Duration and Severity Predict Risk of Hypertension Precursors in a Preclinical Model and Hypertensive Status Among Patients.
Arash GhorbanniaHilda JurkiewiczLith NasifAbdillahi AhmedJennifer Co-VuMehdi MaadooliatRonald K WoodsJohn F LaDisaPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
These findings suggest the current BPGpp threshold determined decades ago is likely too high to prevent adverse coarctation-induced aortic remodeling. The results and decision tree analysis provide a foundation for revising CoA treatment guidelines considering the interaction between CoA severity and duration to limit the risk of hypertension.
Keyphrases
- blood pressure
- arterial hypertension
- fatty acid
- high glucose
- aortic valve
- diabetic rats
- left ventricular
- pulmonary artery
- heart failure
- cell therapy
- drug induced
- oxidative stress
- mesenchymal stem cells
- combination therapy
- aortic dissection
- pulmonary hypertension
- adverse drug
- replacement therapy
- electronic health record