Chitosan Nanoparticles for Intranasal Drug Delivery.
Hossein OmidianErma J GillSumana Dey ChowdhuryLuigi X CubedduPublished in: Pharmaceutics (2024)
This manuscript explores the use of nanostructured chitosan for intranasal drug delivery, targeting improved therapeutic outcomes in neurodegenerative diseases, psychiatric care, pain management, vaccination, and diabetes treatment. Chitosan nanoparticles are shown to enhance brain delivery, improve bioavailability, and minimize systemic side effects by facilitating drug transport across the blood-brain barrier. Despite substantial advancements in targeted delivery and vaccine efficacy, challenges remain in scalability, regulatory approval, and transitioning from preclinical studies to clinical applications. The future of chitosan-based nanomedicines hinges on advancing clinical trials, fostering interdisciplinary collaboration, and innovating in nanoparticle design to overcome these hurdles and realize their therapeutic potential.
Keyphrases
- drug delivery
- pain management
- cancer therapy
- clinical trial
- drug release
- healthcare
- chronic pain
- mental health
- cardiovascular disease
- hyaluronic acid
- glycemic control
- white matter
- randomized controlled trial
- adipose tissue
- mesenchymal stem cells
- current status
- cell therapy
- combination therapy
- health insurance
- insulin resistance
- study protocol
- adverse drug