High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.
Alexander C BashoreHanying YanChenyi XueLucie Y ZhuEunyoung KimThomas MawsonJohana CoronelAllen ChungSebastian HoLeila S RossMichael KissnerEmmanuelle PasseguéRobert C BauerLars MaegdefesselMingyao LiMuredach P ReillyPublished in: medRxiv : the preprint server for health sciences (2023)
Our multimodal atlas of cell populations within atherosclerosis provides novel insights into the diversity, phenotype, location, isolation, and clinical relevance of the unique cellular composition of human carotid atherosclerosis. This facilitates both the mapping of cardiovascular disease susceptibility loci to specific cell types as well as the identification of novel molecular and cellular therapeutic targets for treatment of the disease.
Keyphrases
- single cell
- cardiovascular disease
- rna seq
- endothelial cells
- high throughput
- induced pluripotent stem cells
- cell therapy
- pain management
- pluripotent stem cells
- high resolution
- type diabetes
- genome wide
- stem cells
- dna methylation
- cardiovascular events
- bone marrow
- gene expression
- cardiovascular risk factors
- coronary artery disease
- single molecule
- replacement therapy