The Role of Long Non-Coding RNAs in Osteosarcoma.
Maria Anna SmolleMartin PichlerPublished in: Non-coding RNA (2018)
Long non-coding RNAs (lncRNAs) constitute non-protein coding transcripts with a size > than 200 nucleotides. They are involved in many cellular processes, such as chromatin remodelling, transcription, and gene expression. They play a role in the development, progression, and invasion of many human cancers, including osteosarcoma. This rare tumor entity predominantly arises in children and young adults. Treatment consists of polychemotherapy and surgical resection, increasing survival rates up to 60%. In the present review, the role of lncRNAs with prognostic, predictive, therapeutic, and diagnostic significance in osteosarcoma is discussed. Moreover, their potential application in clinical practice is highlighted.
Keyphrases
- long non coding rna
- gene expression
- young adults
- poor prognosis
- clinical practice
- transcription factor
- endothelial cells
- dna methylation
- dna damage
- network analysis
- genome wide
- binding protein
- induced pluripotent stem cells
- genome wide identification
- cell migration
- human health
- african american
- risk assessment
- small molecule
- replacement therapy