Biomarker-defined pathways for incident type 2 diabetes and coronary heart disease-a comparison in the MONICA/KORA study.

Cornelia HuthAlina BauerAstrid ZiererJulie Sudduth-KlingerChrista MeisingerMichael RodenAnnette PetersWolfgang KoenigChristian Herder Barbara Thorand

Published in: Cardiovascular diabetology (2020)

The biomarker-derived pathway variables explained a higher proportion of the T2D risk compared to CHD. The ranking of the pathways differed between the two diseases, with the IGF/IGFBP-system-pathway being most strongly associated with T2D and the myocardial-injury- and lipid-related-pathways with CHD. Our results help to better understand the pathophysiology of the two diseases, with the ultimate goal of pointing out targets for lifestyle intervention and drug development to ideally prevent both T2D and CHD development.

Keyphrases

type diabetes
cardiovascular disease
randomized controlled trial
physical activity
weight loss
glycemic control
adipose tissue
cell proliferation
pi k akt