Downregulation of LPAR1 Promotes Invasive Behavior in Papillary Thyroid Carcinoma Cells.

Zahra Bokaii HosseiniFatemeh RajabiReza MorovatshoarMahshad AshrafpourPanteha BehboodiDorsa ZareieMohammad Natami

Published in: Cancer informatics (2024)

LPAR1 suppresses metastasis and is linked to EMT, as evidenced by the decreased LPAR1 expression and increased miR-221-5p in PTC. This suggests its potential as a biomarker for diagnosis and prognosis and as a therapeutic target for EMT.

Keyphrases

papillary thyroid
epithelial mesenchymal transition
signaling pathway
lymph node metastasis
poor prognosis
cell proliferation
squamous cell carcinoma
binding protein