Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (2): impacts of post-partum negative energy balance on stromal, glandular and luminal epithelial cells.
Wiruntita ChankeawSandra LignierChristophe RichardTheodoros NtallarisMariam RaliouYongzhi GuoDamien PlassardClaudia BevilacquaOlivier SandraGöran AnderssonPatrice HumblotGilles CharpignyPublished in: BMC genomics (2021)
The severity of NEB after calving is associated with changes in gene expression around 80 days after parturition corresponding to the time of breeding. Specific alterations in GEs are associated with activation of pro-inflammatory mechanisms. Concomitantly, changes in the expression of genes encoding proteins involved in cell interactions and maternal recognition of pregnancy takes place in ST. The combination of these effects possibly altering the uterine environment and embryo maternal interactions may negatively influence the establishment of pregnancy.
Keyphrases
- pregnancy outcomes
- gene expression
- pregnant women
- single cell
- genome wide
- induced apoptosis
- dna methylation
- poor prognosis
- cell cycle arrest
- preterm birth
- birth weight
- bone marrow
- rna seq
- cell therapy
- endometrial cancer
- endoplasmic reticulum stress
- cell death
- binding protein
- high resolution
- physical activity
- cell proliferation
- signaling pathway
- genome wide identification
- weight gain
- weight loss
- bioinformatics analysis