The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function.
Oladapo E OlaniruAttilio PingitoreStefanie GieraXianhua PiaoRamón Castañera GonzálezPeter M JonesShanta Jean PersaudPublished in: Cellular and molecular life sciences : CMLS (2018)
We have demonstrated that collagen III improves islet function by increasing insulin secretion and protecting against apoptosis. Our data suggest that collagen III may be effective in optimising islet function to improve islet transplantation outcomes, and GPR56 may be a target for the treatment of type 2 diabetes.
Keyphrases
- extracellular matrix
- wound healing
- tissue engineering
- fatty acid
- oxidative stress
- electronic health record
- type diabetes
- big data
- cell cycle arrest
- escherichia coli
- adipose tissue
- biofilm formation
- cell proliferation
- skeletal muscle
- signaling pathway
- artificial intelligence
- insulin resistance
- smoking cessation
- pi k akt
- cell adhesion