A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice.

Sylvie M MimcheChoon-Myung LeeKen H LiuPatrice N MimcheR Donald HarveyThomas J MurphyBeatrice A NyagodeDean P JonesTracey J LambEdward T Morgan

Published in: Malaria journal (2019)

These findings in a model of uncomplicated human malaria suggest that changes in drug clearance in this condition may be of sufficient magnitude to cause significant alterations in exposure and response of anti-malarial drugs and co-medications.

Keyphrases

plasmodium falciparum
endothelial cells
drug induced
adverse drug
type diabetes
emergency department
metabolic syndrome
binding protein
induced pluripotent stem cells
long non coding rna
pluripotent stem cells