Opaque Ontology: Neuroimaging Classification of ICD-10 Diagnostic Groups in the UK Biobank.
Ty O EasleyXiaoke LuoKayla HannonPetra LenziniJanine Diane BijsterboschPublished in: bioRxiv : the preprint server for biology (2024)
These findings highlight challenges with the current disease classification system, leading us to recommend caution with the use of ICD-10 diagnostic groups as target labels in brain-based disease prediction studies.