Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus.
Anton Nikolaevich YurchenkoTrinh Hoai Thi PhanElena V Girich IvanetsOlga F SmetaninaAnton B RasinRoman S PopovSergey A DyshlovoyGunhild von AmsbergEkaterina S MenchinskayaTran Thi Thanh VanShamil Sh AfiyatullovPublished in: Marine drugs (2019)
Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 1-10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher's method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.
Keyphrases
- prostate cancer
- endothelial cells
- ms ms
- high resolution
- magnetic resonance
- mycobacterium tuberculosis
- multiple sclerosis
- induced apoptosis
- mass spectrometry
- pluripotent stem cells
- radical prostatectomy
- cell cycle arrest
- electronic health record
- cell death
- polycyclic aromatic hydrocarbons
- deep learning
- drug induced
- anti inflammatory