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High-dose IV magnesium in mesothelioma patients receiving surgery with hyperthermic intraoperative cisplatin: Pilot studies and design of a phase II randomized clinical trial.

Shruti GuptaSophia L WellsArunima M JoseRobert H SeitterLea FeghaliNishant DevarajPhilip M HartiganStephanie YacoubianDavid J KwiatkowskiDonna M BurkeJulianne BarlowRaphael BuenoDavid E Leaf
Published in: Journal of surgical oncology (2023)
A 0.5 g/h infusion for 36 h did not achieve therapeutic magnesium levels, while an infusion at 2 g/h was associated with bradycardia. These studies informed the design of a randomized clinical trial testing whether intravenously Mg attenuates HIOC-associated AKI.
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