Accuracy of World Health Organisation-grade parameters (necrosis and mitotic activity) and foci of vascular invasion in predicting prognosis of papillary thyroid carcinoma. A case-control validation study.
Moira RagazziGiulia BesuttiPamela MancusoPaolo Giorgi RossiAlessia CiarrocchiBenedetta DonatiGloria ManzottiDavide GiordanoAndrea FrasoldatiFederico ChiaruccciDario de de BiaseSara ColuccelliThais MalobertiAntonio De LeoSimonetta PianaGiovanni TalliniPublished in: Histopathology (2024)
Our data strongly support PTC grading, statistically validating World Health Organisation (WHO) criteria to identify poor prognosis PTC. Angioinvasion is not an independent predictor of DM-PTC.