Simvastatin Reduces NETosis to Attenuate Severe Asthma by Inhibiting PAD4 Expression.

Yun-Rong Chen Xu-Dong Xiang Fei Sun Bo-Wen Xiao Mu-Yun Yan Biao Peng Da Liu

Published in: Oxidative medicine and cellular longevity (2023)

Simvastatin reduces Th17-mediated neutrophilic inflammation and airway hyperreactivity by reducing PAD4 expression and inhibiting NETosis in a mouse model of severe asthma. Severe asthmatic patients with high levels of circulating NETs or sputum NETs may show improved responses to statin treatment.

Keyphrases

poor prognosis
mouse model
signaling pathway
cardiovascular disease
oxidative stress
cystic fibrosis
mycobacterium tuberculosis
coronary artery disease
long non coding rna
early onset
lung function
replacement therapy