Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail.
Mysore S VeenaJungmo J GahngMustafa AlaniAlbert Y KoSaroj K BasakIsabelle Y LiuKimberly J HwangJenna R ChatoffNatarajan VenkatesanMarco MorselliWeihong YanIbraheem AliKarolina Elżbieta Kaczor-UrbanowiczBhavani Shankara GowdaPatrick FrostMatteo PellegriniNeda A MoatamedSharon P WilczynskiPascale BomontMarilene B WangDaniel Sanghoon ShinEri S SrivatsanPublished in: Cancer research communications (2024)
Our results suggest that GAN gene exon 8 SNP T allele expression correlates with higher gigaxonin expression and suppression of aggressive cancer cell growth. There is downregulation of Snail and upregulation of e-cadherin through NFκB ubiquitination. We hypothesize that exon 8 T allele and gigaxonin expression could serve as diagnostic markers of suppression of aggressive growth of head and neck cancer.