STEAP3 Affects Ovarian Cancer Progression by Regulating Ferroptosis through the p53/SLC7A11 Pathway.
Yi HanLei FuYan KongChangqing JiangLiying HuangHualing ZhangPublished in: Mediators of inflammation (2024)
Ovarian cancer (OC) is a common malignant cancer in women with a low overall survival rate, and ferroptosis may be a potential new strategy for treatment. Six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a gene closely related to ferroptosis, yet the role of STEAP3 in OC has not yet been thoroughly investigated. Using biological information analysis, we first found that STEAP3 was highly expressed in OC, which was significantly associated with poor prognosis of patients and was an independent prognostic factor. Through cloning, scratch, and transwell experiments, we subsequently found that knockdown of STEAP3 significantly reduced the proliferation and migration ability of OC cells. Furthermore, we found that knockdown of STEAP3 induced ferroptosis in OC cells by detecting ferroptosis indicators. Mechanistically, we also found that knockdown of STEAP3 induced ferroptosis through the p53/SLC7A11 signaling pathway. Through tumorigenic experiments in nude mice, we finally verified that the knockdown of STEAP3 could inhibit tumor growth in vivo by promoting ferroptosis through the p53 pathway. Overall, our study identified a novel therapeutic target for ferroptosis in OC and explored its specific mechanism of action.
Keyphrases
- cell death
- cell cycle arrest
- poor prognosis
- prognostic factors
- induced apoptosis
- signaling pathway
- end stage renal disease
- type diabetes
- high glucose
- diabetic rats
- chronic kidney disease
- newly diagnosed
- healthcare
- endoplasmic reticulum stress
- peritoneal dialysis
- ejection fraction
- copy number
- oxidative stress
- drug induced
- endothelial cells
- mass spectrometry
- metabolic syndrome
- climate change
- young adults
- risk assessment
- lymph node metastasis
- high resolution
- benign prostatic hyperplasia