Secreted Wnt antagonists in scrub typhus.

Thor Ueland Elisabeth AstrupKari OtterdalTove LekvaJeshina JanardhananJohn A J PrakashKurien ThomasAnnika Elisabet MichelsenPål AukrustGeorge M Varghese Jan Kristian Damås

Published in: PLoS neglected tropical diseases (2021)

Our findings suggest that scrub typhus is characterized by attenuated Wnt signaling possibly involving dysregulated levels of several secreted pathway antagonists. The secreted Wnt antagonist SOST was strongly associated with renal dysfunction and poor prognosis in these patients.

Keyphrases

poor prognosis
long non coding rna
end stage renal disease
stem cells
cell proliferation
newly diagnosed
ejection fraction
peritoneal dialysis
patient reported outcomes