Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.
Abigail D WilsonMark A RichardsM Kate CurtisMala Gunadasa-RohlingStefania MonterisiAminah A LoonatJack J J J MillerVicky BallAndrew J M LewisDamian J TylerAnna MoshnikovaOleg A AndreevYana K ReshetnyakCarolyn A CarrPawel SwietachPublished in: Cardiovascular research (2022)
Cardiomyocytes fine-tune the expression of pHi-regulators so that pHi is at least 7.0. This autoregulatory feedback mechanism defines physiological pHi and protects it during pHe vulnerabilities.