Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation.

Nisha PadmanabhanHuang Kie KyonArnoud BootKevin LimSupriya SrivastavaShuwen ChenZhiyuan WuHyung-Ok LeeVineeth T MukundanCharlene ChanYarn Kit ChanOng XuewenJason J PittZul Fazreen Adam IsaManjie XingMing Hui LeeAngie Lay Keng TanShamaine Ho Wei TingMicah A LuftigDennis KappeiWarren D KrugerJinsong BianYing Swan HoMing TehSteve George RozenPatrick Boon-Ooi Tan

Published in: Genome biology (2021)

Our results implicate CBS as a bi-faceted modifier of aberrant DNA methylation and inflammation in GC and highlights H2S donors as a potential new therapy for CBS-silenced lesions.

Keyphrases

dna methylation
oxidative stress
genome wide
gene expression
human health
kidney transplantation
risk assessment
mass spectrometry
climate change
gas chromatography
high resolution