Patrick Boon-Ooi Tan (P Tan, Patrick Tan)

Publication Activity (10 Years)

Years Active: 2020-2023
Publications (10 Years): 41

Top Topics

Dna Methylation

Genome Wide Association

Histone Deacetylase

Top Venues

Nature cell biology

Nature genetics

Cancer research

This page only lists publications with an associated author ORCID identifier.

Publications

Patrick Boon-Ooi Tan, Yunqiang Chu
Single-cell profiling of gastric cardia adenocarcinoma reveals drivers of cancer stemness and therapeutic targets. Gut (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology 25 (5) (2023)
Jinghong Chen, Chern Han Yong, Hong Lee Heng, Jason Yongsheng Chan, Mai Chan Lau, Jianfeng Chen, Jing Yi Lee, Abner Herbert Lim, Zhimei Li, Peiyong Guan, Pek Lim Chu, Arnoud Boot, Sheng Rong Ng, Xiaosai Yao, Felicia Yu Ting Wee, Jeffrey Chun Tatt Lim, Wei Liu, Peili Wang, Rong Xiao, Xian Zeng, Yichen Sun, Joanna Koh, Xiu Yi Kwek, Cedric Chuan Young Ng, Poramate Klanrit, Yaojun Zhang, Jiaming Lai, David Wai Meng Tai, Chawalit Pairojkul, Simona Dima, Irinel Popescu, Sen-Yung Hsieh, Ming-Chin Yu, Joe Poh Sheng Yeong, Sarinya Kongpetch, Apinya Jusakul, Watcharin Loilome, Patrick Boon-Ooi Tan, Jing Tan, Bin Tean Teh
Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies. Gut (2023)
Eleanor Wong, Nicolas Bertin, Maxime Hebrard, Roberto Tirado-Magallanes, Claire Bellis, Weng Khong Lim, Chee Yong Chua, Philomena Mei Lin Tong, Raymond Chua, Kenneth Mak, Tit Meng Lim, Wei Yang Cheong, Kwee Eng Thien, Khean Teik Goh, Jin Fang Chai, Jimmy Lee, Joseph Jao Yiu Sung, Tien Yin Wong, Calvin Woon Loong Chin, Peter D Gluckman, Liuh Ling Goh, Kenneth Hon Kim Ban, Tin Wee Tan, null null, Xueling S Sim, Ching-Yu Cheng, Sonia Davila, Neerja Karnani, Khai Pang Leong, Jian-Jun Liu, Shyam Prabhakar, Sebastian Mauer-Stroh, Chandra Shekhar Verma, Pavitra Krishnaswamy, Rick Siow Mong Goh, Irenaeus Chia, Clarissa Ho, Doreen Low, Suchin Virabhak, Jacklyn Yong, Weiling Zheng, Shih Wee Seow, Yee Kwang Seck, Mingshi Koh, John C Chambers, E-Shyong Tai, Patrick Boon-Ooi Tan
The Singapore National Precision Medicine Strategy. Nature genetics 55 (2) (2023)
Takahiko Akiyama, Tadahito Yasuda, Tomoyuki Uchihara, Noriko Yasuda-Yoshihara, Benjy Jek Yang Tan, Atsuko Yonemura, Takashi Semba, Juntaro Yamasaki, Yoshihiro Komohara, Koji Ohnishi, Feng Wei, Lingfeng Fu, Jun Zhang, Fumimasa Kitamura, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Hirotake Tsukamoto, Terumasa Umemoto, Mari Masuda, Osamu Nagano, Yorifumi Satou, Hideyuki Saya, Patrick Boon-Ooi Tan, Hideo Baba, Takatsugu Ishimoto
Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors. Cancer research 83 (5) (2023)
Takahiko Akiyama, Tadahito Yasuda, Tomoyuki Uchihara, Noriko Yasuda-Yoshihara, Benjy Jek Yang Tan, Atsuko Yonemura, Takashi Semba, Juntaro Yamasaki, Yoshihiro Komohara, Koji Ohnishi, Feng Wei, Lingfeng Fu, Jun Zhang, Fumimasa Kitamura, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Hirotake Tsukamoto, Terumasa Umemoto, Mari Masuda, Osamu Nagano, Yorifumi Satou, Hideyuki Saya, Patrick Boon-Ooi Tan, Hideo Baba, Takatsugu Ishimoto
Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors. Cancer research 83 (5) (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology (2023)
Eleanor Wong, Nicolas Bertin, Maxime Hebrard, Roberto Tirado-Magallanes, Claire Bellis, Weng Khong Lim, Chee Yong Chua, Philomena Mei Lin Tong, Raymond Chua, Kenneth Mak, Tit Meng Lim, Wei Yang Cheong, Kwee Eng Thien, Khean Teik Goh, Jin Fang Chai, Jimmy Lee, Joseph Jao Yiu Sung, Tien Yin Wong, Calvin Woon Loong Chin, Peter D Gluckman, Liuh Ling Goh, Kenneth Hon Kim Ban, Tin Wee Tan, null null, Xueling S Sim, Ching-Yu Cheng, Sonia Davila, Neerja Karnani, Khai Pang Leong, Jian-Jun Liu, Shyam Prabhakar, Sebastian Mauer-Stroh, Chandra Shekhar Verma, Pavitra Krishnaswamy, Rick Siow Mong Goh, Irenaeus Chia, Clarissa Ho, Doreen Low, Suchin Virabhak, Jacklyn Yong, Weiling Zheng, Shih Wee Seow, Yee Kwang Seck, Mingshi Koh, John C Chambers, E-Shyong Tai, Patrick Boon-Ooi Tan
The Singapore National Precision Medicine Strategy. Nature genetics 55 (2) (2023)
Chang Xu, Kie Kyon Huang, Jia Hao Law, Joy Shijia Chua, Taotao Sheng, Natasha M Flores, Melissa Pool Pizzi, Atsushi Okabe, Angie Lay Keng Tan, Feng Zhu, Vikrant Kumar, Xiaoyin Lu, Ana Morales Benitez, Benedict Shi Xiang Lian, Haoran Ma, Shamaine Wei Ting Ho, Kalpana Ramnarayanan, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Siti Aishah Binte Abdul Ghani, Su Ting Tay, Xuewen Ong, Ming Hui Lee, Yu Amanda Guo, Hassan Ashktorab, Duane Smoot, Shang Li, Anders Jacobsen Skanderup, Michael A Beer, Roger Sik Yin Foo, Joel Shi Hao Wong, Kaushal Sanghvi, Wei Peng Yong, Raghav Sundar, Atsushi Kaneda, Shyam Prabhakar, Pawel Karol Mazur, Jaffer A Ajani, Khay-Guan Yeoh, Jimmy Bok-Yan So, Patrick Boon-Ooi Tan, null null
Comprehensive molecular phenotyping of ARID1A -deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities. Gut (2023)
Lukas F K Kuderna, Jacob C Ulirsch, Sabrina Rashid, Mohamed Ameen, Laksshman Sundaram, Glenn Hickey, Anthony J Cox, Hong Gao, Arvind Kumar, François Aguet, Matthew J Christmas, Hiram Clawson, Maximilian Haeussler, Mareike C Janiak, Martin Kuhlwilm, Joseph D Orkin, Thomas Bataillon, Shivakumara Manu, Alejandro Valenzuela, Juraj Bergman, Marjolaine Rousselle, Felipe Ennes Silva, Lidia Agueda, Julie Marie Blanc, Marta Gut, Dorien de Vries, Ian B Goodhead, R Alan Harris, Muthuswamy Raveendran, Axel Jensen, Idriss S Chuma, Julie E Horvath, Christina Hvilsom, David Juan, Peter Frandsen, Joshua G Schraiber, Fabiano R de Melo, Fabrício Bertuol, Hazel Byrne, Iracilda Sampaio, Izeni Pires Farias, João Valsecchi do Amaral, Malu Messias, Maria N F da Silva, Mihir Trivedi, Rogerio Rossi, Tomas Hrbek, Nicole Andriaholinirina, Clément J Rabarivola, Alphonse Zaramody, Clifford J Jolly, Jane Phillips-Conroy, Gregory K Wilkerson, Christian Abee, Joe H Simmons, Eduardo Fernández-Duque, Sree Kanthaswamy, Fekadu Shiferaw, Dong-Dong Wu, Long Zhou, Yong Shao, Guojie Zhang, Julius D Keyyu, Sascha Knauf, Minh D Le, Esther Lizano, Stefan Merker, Arcadi Navarro, Tilo Nadler, Chiea Chuen Khor, Jessica Lee, Patrick Boon-Ooi Tan, Weng Khong Lim, Andrew C Kitchener, Dietmar Zinner, Ivo Glynne Gut, Amanda Dawn Melin, Katerina Guschanski, Mikkel Heide Schierup, Robin M D Beck, Ioannis Karakikes, Kevin C Wang, Govindhaswamy Umapathy, Christian Roos, Jean Phillipe Boubli, Adam C Siepel, Anshul Kundaje, Benedict Paten, Kerstin Lindblad-Toh, Jeffrey Rogers, Tomas Marques-Bonet, Kyle Kai-How Farh
Identification of constrained sequence elements across 239 primate genomes. Nature (2023)
Hong Gao, Tobias Hamp, Jeffrey Ede, Joshua G Schraiber, Jeremy F McRae, Moriel H Singer-Berk, Yanshen Yang, Anastasia S D Dietrich, Petko P Fiziev, Lukas F K Kuderna, Laksshman Sundaram, Yibing Wu, Aashish N Adhikari, Yair Field, Chen Chen, Serafim Batzoglou, François Aguet, Gabrielle Lemire, Rebecca Reimers, Daniel J Balick, Mareike C Janiak, Martin Kuhlwilm, Joseph D Orkin, Shivakumara Manu, Alejandro Valenzuela, Juraj Bergman, Marjolaine Rousselle, Felipe Ennes Silva, Lidia Agueda, Julie Marie Blanc, Marta Gut, Dorien de Vries, Ian B Goodhead, Ronald Alan Harris, Muthuswamy Raveendran, Axel Jensen, Idrissa S Chuma, Julie E Horvath, Christina Hvilsom, David Juan, Peter Frandsen, Fabiano Rodrigues de Melo, Fabrício Bertuol, Hazel Byrne, Iracilda Sampaio, Izeni Pires Farias, João Valsecchi do Amaral, Mariluce Rezende Messias, Maria N F da Silva, Mihir Trivedi, Rogério Vieira Rossi, Tomas Hrbek, Nicole Andriaholinirina, Clément J Rabarivola, Alphonse Zaramody, Clifford J Jolly, Jane E Phillips-Conroy, Gregory K Wilkerson, Christian Abee, Joe H Simmons, Eduardo Fernández-Duque, Sree Kanthaswamy, Fekadu Shiferaw, Dong-Dong Wu, Long Zhou, Yong Shao, Guo-Jie Zhang, Julius D Keyyu, Sascha Knauf, Quyen Hanh Do, Esther Lizano, Stefan Merker, Arcadi Navarro, Thomas Bataillon, Tilo Nadler, Chiea Chuen Khor, Jessica Lee, Patrick Boon-Ooi Tan, Weng Khong Lim, Andrew C Kitchener, Dietmar Zinner, Ivo Glynne Gut, Amanda Dawn Melin, Katerina Guschanski, Mikkel Heide Schierup, Robin M D Beck, Govindhaswamy Umapathy, Christian Roos, Jean Phillipe Boubli, Monkol Lek, Shamil R Sunyaev, Anne H O'Donnell-Luria, Michael J Bamshad, Jinbo Xu, Jeffrey Rogers, Tomas Marques-Bonet, Kyle Kai-How Farh
The landscape of tolerated genetic variation in humans and primates. Science (New York, N.Y.) 380 (6648) (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology 25 (5) (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology 25 (5) (2023)
Qiao Fan, Hengtong Li, Xiaomeng Wang, Yih-Chung Tham, Kelvin Yi Chong Teo, Masayuki Yasuda, Weng Khong Lim, Yuet Ping Kwan, Jing Xian Teo, Ching-Jou Chen, Li Jia Chen, Jeeyun Ahn, Sonia Davila, Masahiro Miyake, Patrick Boon-Ooi Tan, Kyu Hyung Park, Chi Pui Pang, Chiea Chuen Khor, Tien-Yin Wong, Yasuo Yanagi, Chui Ming Gemmy Cheung, Ching-Yu Cheng
Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes. Nature communications 14 (1) (2023)
Lukas F K Kuderna, Hong Gao, Mareike C Janiak, Martin Kuhlwilm, Joseph D Orkin, Thomas Bataillon, Shivakumara Manu, Alejandro Valenzuela, Juraj Bergman, Marjolaine Rousselle, Felipe Ennes Silva, Lidia Agueda, Julie Marie Blanc, Marta Gut, Dorien de Vries, Ian B Goodhead, Ronald Alan Harris, Muthuswamy Raveendran, Axel Jensen, Idrissa S Chuma, Julie E Horvath, Christina Hvilsom, David Juan, Peter Frandsen, Joshua G Schraiber, Fabiano Rodrigues de Melo, Fabrício Bertuol, Hazel Byrne, Iracilda Sampaio, Izeni Pires Farias, João Valsecchi do Amaral, Mariluce Rezende Messias, Maria N F da Silva, Mihir Trivedi, Rogério Vieira Rossi, Tomas Hrbek, Nicole Andriaholinirina, Clément J Rabarivola, Alphonse Zaramody, Clifford J Jolly, Jane E Phillips-Conroy, Gregory K Wilkerson, Christian Abee, Joe H Simmons, Eduardo Fernández-Duque, Sree Kanthaswamy, Fekadu Shiferaw, Dong-Dong Wu, Long Zhou, Yong Shao, Guo-Jie Zhang, Julius D Keyyu, Sascha Knauf, Quyen Hanh Do, Esther Lizano, Stefan Merker, Arcadi Navarro, Tilo Nadler, Chiea Chuen Khor, Jessica Lee, Patrick Boon-Ooi Tan, Weng Khong Lim, Andrew C Kitchener, Dietmar Zinner, Ivo Glynne Gut, Amanda Dawn Melin, Katerina Guschanski, Mikkel Heide Schierup, Robin M D Beck, Govindhaswamy Umapathy, Christian Roos, Jean Phillipe Boubli, Jeffrey Rogers, Kyle Kai-How Farh, Tomas Marques-Bonet
A global catalog of whole-genome diversity from 233 primate species. Science (New York, N.Y.) 380 (6648) (2023)
Eleanor Wong, Nicolas Bertin, Maxime Hebrard, Roberto Tirado-Magallanes, Claire Bellis, Weng Khong Lim, Chee Yong Chua, Philomena Mei Lin Tong, Raymond Chua, Kenneth Mak, Tit Meng Lim, Wei Yang Cheong, Kwee Eng Thien, Khean Teik Goh, Jin Fang Chai, Jimmy Lee, Joseph Jao Yiu Sung, Tien Yin Wong, Calvin Woon Loong Chin, Peter D Gluckman, Liuh Ling Goh, Kenneth Hon Kim Ban, Tin Wee Tan, null null, Xueling S Sim, Ching-Yu Cheng, Sonia Davila, Neerja Karnani, Khai Pang Leong, Jian-Jun Liu, Shyam Prabhakar, Sebastian Mauer-Stroh, Chandra Shekhar Verma, Pavitra Krishnaswamy, Rick Siow Mong Goh, Irenaeus Chia, Clarissa Ho, Doreen Low, Suchin Virabhak, Jacklyn Yong, Weiling Zheng, Shih Wee Seow, Yee Kwang Seck, Mingshi Koh, John C Chambers, E-Shyong Tai, Patrick Boon-Ooi Tan
The Singapore National Precision Medicine Strategy. Nature genetics 55 (2) (2023)
Lyla J Stanland, Hazel Xiaohui Ang, Jacob P Hoj, Yunqiang Chu, Patrick Boon-Ooi Tan, Kris C Wood, Micah A Luftig
CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer. Molecular cancer research : MCR (2023)
Eleanor Wong, Nicolas Bertin, Maxime Hebrard, Roberto Tirado-Magallanes, Claire Bellis, Weng Khong Lim, Chee Yong Chua, Philomena Mei Lin Tong, Raymond Chua, Kenneth Mak, Tit Meng Lim, Wei Yang Cheong, Kwee Eng Thien, Khean Teik Goh, Jin Fang Chai, Jimmy Lee, Joseph Jao Yiu Sung, Tien Yin Wong, Calvin Woon Loong Chin, Peter D Gluckman, Liuh Ling Goh, Kenneth Hon Kim Ban, Tin Wee Tan, null null, Xueling S Sim, Ching-Yu Cheng, Sonia Davila, Neerja Karnani, Khai Pang Leong, Jian-Jun Liu, Shyam Prabhakar, Sebastian Mauer-Stroh, Chandra Shekhar Verma, Pavitra Krishnaswamy, Rick Siow Mong Goh, Irenaeus Chia, Clarissa Ho, Doreen Low, Suchin Virabhak, Jacklyn Yong, Weiling Zheng, Shih Wee Seow, Yee Kwang Seck, Mingshi Koh, John C Chambers, E-Shyong Tai, Patrick Boon-Ooi Tan
The Singapore National Precision Medicine Strategy. Nature genetics (2023)
Takahiko Akiyama, Tadahito Yasuda, Tomoyuki Uchihara, Noriko Yasuda-Yoshihara, Benjy Jek Yang Tan, Atsuko Yonemura, Takashi Semba, Juntaro Yamasaki, Yoshihiro Komohara, Koji Ohnishi, Feng Wei, Lingfeng Fu, Jun Zhang, Fumimasa Kitamura, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Hirotake Tsukamoto, Terumasa Umemoto, Mari Masuda, Osamu Nagano, Yorifumi Satou, Hideyuki Saya, Patrick Boon-Ooi Tan, Hideo Baba, Takatsugu Ishimoto
Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors. Cancer research (2022)
Yong Xiang Gwee, Daryl Kai Ann Chia, Jimmy So, Wim P Ceelen, Wei Peng Yong, Patrick Boon-Ooi Tan, Chin-Ann Johnny Ong, Raghav Sundar
Integration of Genomic Biology Into Therapeutic Strategies of Gastric Cancer Peritoneal Metastasis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 40 (24) (2022)
Sock Hoai Chan, Yasmin Bylstra, Jing Xian Teo, Jyn Ling Kuan, Nicolas Bertin, Mar Gonzalez-Porta, Maxime Hebrard, Roberto Tirado-Magallanes, Joanna Hui Juan Tan, Justin Jeyakani, Zhihui Li, Jin Fang Chai, Yap Seng Chong, Sonia Davila, Liuh Ling Goh, Eng Sing Lee, Eleanor Wong, Tien Yin Wong, null null, Shyam Prabhakar, Jian-Jun Liu, Ching-Yu Cheng, Birgit Eisenhaber, Neerja Karnani, Khai Pang Leong, Xueling S Sim, Khung Keong Yeo, John C Chambers, E-Shyong Tai, Patrick Boon-Ooi Tan, Saumya Shekhar Jamuar, Joanne Ngeow Yuen Yie, Weng Khong Lim
Analysis of clinically relevant variants from ancestrally diverse Asian genomes. Nature communications 13 (1) (2022)
Weizhuang Zhou, Yu En Chan, Chuan Sheng Foo, Jingxian Zhang, Jing Xian Teo, Sonia Davila, Weiting Huang, Jonathan J L Yap, Stuart Alexander Cook, Patrick Boon-Ooi Tan, Calvin Woon-Loong Chin, Khung Keong Yeo, Weng Khong Lim, Pavitra Krishnaswamy
High-Resolution Digital Phenotypes From Consumer Wearables and Their Applications in Machine Learning of Cardiometabolic Risk Markers: Cohort Study. Journal of medical Internet research 24 (7) (2022)
Amrita M Nargund, Chang Xu, Amit Mandoli, Atsushi Okabe, Gao Bin Chen, Kie Kyon Huang, Taotao Sheng, Xiaosai Yao, Jia Ming Nickolas Teo, Raghav Sundar, Yee Jiun Kok, Yi Xiang See, Manjie Xing, Zhimei Li, Chern Han Yong, Aparna Anand, Zul Fazreen A I, Lai Fong Poon, Michelle Shu Wen Ng, Javier Yu Peng Koh, Wen Fong Ooi, Su Ting Tay, Xuewen Ong, Angie Lay Keng Tan, Heike I Grabsch, Melissa J Fullwood, Tean Bin Teh, Xuezhi Bi, Atsushi Kaneda, Shang Li, Patrick Boon-Ooi Tan
Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer. Cancer research 82 (14) (2022)
Shamaine Wei Ting Ho, Taotao Sheng, Manjie Xing, Wen Fong Ooi, Chang Xu, Raghav Sundar, Kie Kyon Huang, Zhimei Li, Vikrant Kumar, Kalpana Ramnarayanan, Feng Zhu, Supriya Srivastava, Zul Fazreen Bin Adam Isa, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Dustin Shigaki, Haoran Ma, Angie Lay Keng Tan, Xuewen Ong, Ming Hui Lee, Su Ting Tay, Yu Amanda Guo, Weitai Huang, Shang Li, Michael A Beer, Roger Sik Yin Foo, Ming Teh, Anders Jacobsen Skanderup, Bin Tean Teh, Patrick Boon-Ooi Tan
Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities. Gut (2022)
Toshikazu Ushijima, Susan J Clark, Patrick Boon-Ooi Tan
Mapping genomic and epigenomic evolution in cancer ecosystems. Science (New York, N.Y.) 373 (6562) (2021)
A Fatehullah, Y Terakado, S Sagiraju, T L Tan, T Sheng, S H Tan, K Murakami, Y Swathi, N Ang, Ravisankar Rajarethinam, T Ming, Patrick Boon-Ooi Tan, B Lee, Nick Barker
A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers. Nature cell biology (2021)
Nisha Padmanabhan, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, Hyung-Ok Lee, Vineeth T Mukundan, Charlene Chan, Yarn Kit Chan, Ong Xuewen, Jason J Pitt, Zul Fazreen Adam Isa, Manjie Xing, Ming Hui Lee, Angie Lay Keng Tan, Shamaine Ho Wei Ting, Micah A Luftig, Dennis Kappei, Warren D Kruger, Jinsong Bian, Ying Swan Ho, Ming Teh, Steve George Rozen, Patrick Boon-Ooi Tan
Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation. Genome biology 22 (1) (2021)
Ruby E Dawson, Virginie Deswaerte, Alison C West, Ke Tang, Alice J West, Jesse J Balic, Linden J Gearing, Mohamed I Saad, Liang Yu, Yonghui Wu, Prithi S Bhathal, Beena Kumar, Jayati T Chakrabarti, Yana Zavros, Hiroko Oshima, Dennis M Klinman, Masanobu Oshima, Patrick Boon-Ooi Tan, Brendan J Jenkins
STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis. Gut (2021)
Weiqin Yang, Yu Feng, Jingying Zhou, Otto Ka-Wing Cheung, Jianquan Cao, Jing Wang, Wenshu Tang, Yalin Tu, Liangliang Xu, Feng Wu, Zhiwu Tan, Hanyong Sun, Yuan Tian, John Wong, Paul Bo San Lai, Stephen Lam Chan, Anthony Wing-Hung Chan, Patrick Boon-Ooi Tan, Zhiwei Chen, Joseph Jao Yiu Sung, Kevin Yuk-Lap Yip, Ka-Fai To, Alfred Sze-Lok Cheng
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma. Science translational medicine 13 (588) (2021)
Xuling Chang, Resham L Gurung, Ling Wang, Aizhen Jin, Zheng Li, Renwei Wang, Kenneth B Beckman, Jennifer Adams-Haduch, Wee Yang Meah, Kar-Seng Sim, Weng Khong Lim, Sonia Davila, Patrick Boon-Ooi Tan, Jing Xian Teo, Khung Keong Yeo, Yiamunaa M, Sylvia Liu, Su Chi Lim, Jian-Jun Liu, Rob M van Dam, Yechiel Friedlander, Woon-Puay Koh, Woon-Puay Koh, Chiea Chuen Khor, Chew-Kiat Heng, Rajkumar Dorajoo
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population. Communications biology 4 (1) (2021)
Yasmin Bylstra, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R Ryanne Wu, Jing Xian Teo, Sonia Davila, Jyn Ling Kuan, Sock Hoai Chan, Nicolas Bertin, Cheng Xi Yang, Steve Rozen, Bin Tean Teh, Khung Keong Yeo, Stuart Alexander Cook, Saumya Shekhar Jamuar, Geoffrey S Ginsburg, Lori A Orlando, Patrick Boon-Ooi Tan
Family history assessment significantly enhances delivery of precision medicine in the genomics era. Genome medicine 13 (1) (2021)
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